4: 4′ Diamidino-Diphenyl-Ether in the Treatment of Indian Kala-Azar

The Treatment of Kala-Azar by Diamidino Stilbene : Analysis of 101 Cases

Introduction.?About eighteen months ago, we (Napier and Sen, 1940) published a preliminary paper on the treatment of kala-azar by 4 : 4'-diamidino stilbene. At the time our paper was sent to press, there were in the literature? that had arrived in this country?only two detailed reports on cases treated by this drug (Adams and Yorke, 1939; and Adler and Rachmilewitz, 1939). Since then a small sp...

Hydroxystilbamidine in the Treatment of Indian Kala-Azar *A lengthy protocol containing a summary of clinical notes of the 42 cases treated and accompanying this paper has been omitted to save space.—Editor, I.M.G.

Hydroxystilbamidine or 4 : 4'-diamidino 2-hydroxy-stilbene di-jS-hydroxy-ethane sulphonate was first used by the writer for the treatment of kala-azar in 1948 and 1949 and a paper based on the results of treatment of the first six cases published (Sen Gupta, 1949). All the six cases treated had recovered and had remained free from all symptoms of kala-azar for 5, 5, 5, 4}2-, 34, and 3 months re...

Diamidino-Stilbene in the Treatment of Kala-Azar

The Treatment of Kala-Azar with Diamidino-Di-Phenoxy-Pentane. Preliminary Observations on the Treatment of 32 Cases

Observations on the Neuropathic Sequel of Diamidino-Stilbene Therapy in Kala-Azar

Diamidino-stilbene is by far the most potent of the aromatic diamidines tested so far in the treatment of kala-azar. The immediate cure rate in Indian kala-azar is about 98 per cent, and the proportion of cases relapsing after a single course of treatment is very low. The use of this drug has however certain drawbacks. The intravenous injections are usually accompanied by certain unpleasant rea...